diff --git a/src/libImaging/Unpack.c b/src/libImaging/Unpack.c
index ab5f2c158..203bcac2c 100644
--- a/src/libImaging/Unpack.c
+++ b/src/libImaging/Unpack.c
@@ -1833,6 +1833,7 @@ static struct {
     {IMAGING_MODE_I_16N, IMAGING_RAWMODE_I_16N, 16, copy2},
 
     {IMAGING_MODE_I_16, IMAGING_RAWMODE_I_16B, 16, unpackI16B_I16},
+    {IMAGING_MODE_I_16B, IMAGING_RAWMODE_I_16N, 16, unpackI16N_I16B},
     {IMAGING_MODE_I_16, IMAGING_RAWMODE_I_16R, 16, unpackI16R_I16},
 
     // LibTiff native->image endian.