diff --git a/.evergreen/config.yml b/.evergreen/config.yml
index 053dc0cde..6ab459e42 100644
--- a/.evergreen/config.yml
+++ b/.evergreen/config.yml
@@ -1846,6 +1846,10 @@ axes:
         display_name: "Python 3.9"
         variables:
           PYTHON_BINARY: "/opt/python/3.9/bin/python3"
+      - id: "3.10"
+        display_name: "Python 3.10"
+        variables:
+          PYTHON_BINARY: "/opt/python/3.10/bin/python3"
       - id: "pypy3.6"
         display_name: "PyPy 3.6"
         variables:
@@ -1878,6 +1882,10 @@ axes:
         display_name: "Python 3.9"
         variables:
           PYTHON_BINARY: "C:/python/Python39/python.exe"
+      - id: "3.10"
+        display_name: "Python 3.10"
+        variables:
+          PYTHON_BINARY: "C:/python/Python310/python.exe"
 
   - id: python-version-windows-32
     display_name: "Python"
@@ -1898,6 +1906,10 @@ axes:
         display_name: "32-bit Python 3.9"
         variables:
           PYTHON_BINARY: "C:/python/32/Python39/python.exe"
+      - id: "3.10"
+        display_name: "32-bit Python 3.10"
+        variables:
+          PYTHON_BINARY: "C:/python/32/Python310/python.exe"
 
   # Choice of mod_wsgi version
   - id: mod-wsgi-version
@@ -2144,6 +2156,17 @@ buildvariants:
   display_name: "${python-version} ${platform} ${auth-ssl} ${coverage}"
   tasks: *all-server-versions
 
+- matrix_name: "tests-python-version-ubuntu20-ssl"
+  matrix_spec:
+    platform: ubuntu-20.04
+    python-version: ["3.10"]
+    auth-ssl: "*"
+  display_name: "${python-version} ${platform} ${auth-ssl} ${coverage}"
+  tasks:
+    - ".latest"
+    - ".5.0"
+    - ".4.4"
+
 - matrix_name: "tests-pyopenssl"
   matrix_spec:
     platform: awslinux
diff --git a/setup.py b/setup.py
index f09e2c6f0..88ec93a00 100755
--- a/setup.py
+++ b/setup.py
@@ -17,11 +17,15 @@ except ImportError:
 
 from setuptools import setup, __version__ as _setuptools_version
 
-from distutils.cmd import Command
-from distutils.command.build_ext import build_ext
-from distutils.errors import CCompilerError, DistutilsOptionError
-from distutils.errors import DistutilsPlatformError, DistutilsExecError
-from distutils.core import Extension
+
+if sys.version_info[:2] < (3, 10):
+    from distutils.cmd import Command
+    from distutils.command.build_ext import build_ext
+    from distutils.core import Extension
+else:
+    from setuptools import Command
+    from setuptools.command.build_ext import build_ext
+    from setuptools.extension import Extension
 
 _HAVE_SPHINX = True
 try:
@@ -82,7 +86,7 @@ class test(Command):
         if self.test_suite is None and self.test_module is None:
             self.test_module = 'test'
         elif self.test_module is not None and self.test_suite is not None:
-            raise DistutilsOptionError(
+            raise Exception(
                 "You may specify a module or suite, but not both"
             )
 
@@ -176,15 +180,6 @@ class doc(Command):
                          "   %s/\n" % (mode, path))
 
 
-if sys.platform == 'win32':
-    # distutils.msvc9compiler can raise an IOError when failing to
-    # find the compiler
-    build_errors = (CCompilerError, DistutilsExecError,
-                    DistutilsPlatformError, IOError)
-else:
-    build_errors = (CCompilerError, DistutilsExecError, DistutilsPlatformError)
-
-
 class custom_build_ext(build_ext):
     """Allow C extension building to fail.
 
@@ -237,7 +232,7 @@ https://pymongo.readthedocs.io/en/stable/installation.html#osx
     def run(self):
         try:
             build_ext.run(self)
-        except DistutilsPlatformError:
+        except Exception:
             e = sys.exc_info()[1]
             sys.stdout.write('%s\n' % str(e))
             warnings.warn(self.warning_message % ("Extension modules",
@@ -249,7 +244,7 @@ https://pymongo.readthedocs.io/en/stable/installation.html#osx
         name = ext.name
         try:
             build_ext.build_extension(self, ext)
-        except build_errors:
+        except Exception:
             e = sys.exc_info()[1]
             sys.stdout.write('%s\n' % str(e))
             warnings.warn(self.warning_message % ("The %s extension "
diff --git a/test/utils.py b/test/utils.py
index 02a0a5883..ae75d7647 100644
--- a/test/utils.py
+++ b/test/utils.py
@@ -15,7 +15,6 @@
 """Utilities for testing pymongo
 """
 
-import collections
 import contextlib
 import copy
 import functools
@@ -27,7 +26,7 @@ import threading
 import time
 import warnings
 
-from collections import defaultdict
+from collections import abc, defaultdict
 from functools import partial
 
 from bson import json_util
@@ -300,11 +299,11 @@ class ScenarioDict(dict):
     """Dict that returns {} for any unknown key, recursively."""
     def __init__(self, data):
         def convert(v):
-            if isinstance(v, collections.Mapping):
+            if isinstance(v, abc.Mapping):
                 return ScenarioDict(v)
             if isinstance(v, (str, bytes)):
                 return v
-            if isinstance(v, collections.Sequence):
+            if isinstance(v, abc.Sequence):
                 return [convert(item) for item in v]
             return v